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KMID : 0882420070720050511
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Korean Journal of Medicine
2007 Volume.72 No. 5 p.511 ~ p.521
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Association between apolipoprotein E genetic polymorphism and the development of microalbuminuria in type 2 diabetic patients
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Kwon Mi-Kwang
Rhee Sang-Youl
Chon Suk
Oh Seung-Joon
Woo Jeong-Taek
Kim Sung-Woon
Kim Jin-Woo
Kim Young-Seol
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Abstract
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Background : Apo E genetic polymorphism has been proposed as the one of the risk factors for diabetic nephropathy. We studied the association between Apo E genetic polymorphism and the development of microalbuminuria, which is the early stage of diabetic nephropathy.
Methods : Fifty eight subjects with normoalbuminuria and Thirty six subjects with microalbuminuria were enrolled. They were all type 2 diabetic patients who had normal renal function and a history of diabetes longer than a 10 years duration. We examined the mean HbA1c, total cholesterol and triglyceride levels for 10 years, and we also examined
several clinical characteristics. We determined the Apo E genotype by performing real time PCR.
Results : In the microalbuminuria group, compared with the normoalbuminuria group, the HbA1c (7.6±1.3% vs 7.0±0.9%, respectively, p=0.012) and mean creatinine (1.2±0.7 mg/dL vs 1.0±0.2 mg/dL, respectively, p=0.004) levels were
significantly higher, and the frequencies of the e3/e4 genotype (5.6% vs 20.7%, respectively, p=0.045) and the E4 carriers
(5.9% vs 22.8%, respectively, p=0.035) were significantly lower. On logistic regression analysis, the crude odds ratio of
being an E2 carrier and being an E4 carrier were 0.833 (95% CI: 0.245-2.833) and 0.205 (95% CI: 0.043-0.986),
respectively. However, the odds ratio after adjusted by HbA1c, hypertension, total cholesterol and triglyceride were 0.664
(95% CI: 0.134-3.289) and 0.365 (95% CI: 0.061-2.187), respectively. There were no correlations between being an Apo
E carrier and the lipid levels in the healthy controls and diabetic patients.
Conclusions : Being an E4 carrier might play a role in protecting against the development of microalbuminuria in
type 2 diabetic patients and there was no correlation among the Apo E genetic polymorphisms and the lipid
levels.(Korean J Med 72:511-521, 2007)
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KEYWORD
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Diabetes mellitus, Type 2, Apo E genetic polymorphisms, Microalbuminuira
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